Class11_Vocal+Communication2010

Class11_Vocal Commun - Outline FOXP2 Vocal Communication Mutation in humans Manipulation in mice Expression with learning in songbirds Human

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1 Vocal Communication Outline FOXP2 – Mutation in humans – Manipulation in mice – Expression with learning in songbirds • Human language circuits Vocal communication: language Genetic factors (development of brain) Environment (learning) Vocal communication/language Language Disorders Verbal Dyspraxia: An impaired ability to perform the coordinated movements that are required for speech • In one family (KE), it appears that this disorder is caused by a mutation to the FOXP2 gene – Effects are more stronger with articulation of speech rather than comprehension Language Disorders Language development depends on experience during a sensitive period . A mutation of the FOXP2 gene delays learning to speak Figure 19.1 A Heritable Language Disorder (Part 1)
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2 Figure 19.1 A Heritable Language Disorder (Part 2) The FOXP2 Gene • Transcriptional factor – Controls the expression of other genes • FOXP2 gene is very different in humans than in apes, suggesting rapid evolution of this gene • In several species expressed in brain areas associated with vocal learning Comparative Method Other species display vocalizations. Sounds may distinguish species, signal readiness to mate, or alert others to danger. A parallel to humans is that mice with FOXP2 mutations have impaired vocalization. Outline FOXP2 – Mutation in humans – Manipulation in mice – Expression with learning in songbirds • Human language circuits Singing Mice? • Mice vocalizations are ultrasonic (very high frequency) • Genetically identical male mice show individual differences in vocalizations
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3 Copyright ©2005 by the National Academy of Sciences Shu, Weiguo et al. (2005) Proc. Natl. Acad. Sci. USA 102, 9643-9648 Fig. 4. Vocalization and behavior in mice with a disruption of the Foxp2 locus
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This note was uploaded on 11/08/2010 for the course PSC Psychology taught by Professor Cossowings during the Spring '08 term at UC Davis.

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Class11_Vocal Commun - Outline FOXP2 Vocal Communication Mutation in humans Manipulation in mice Expression with learning in songbirds Human

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