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Class11_Vocal+Communication2010

Class11_Vocal+Communication2010 - Outline FOXP2 Vocal...

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1 Vocal Communication Outline FOXP2 – Mutation in humans – Manipulation in mice – Expression with learning in songbirds Human language circuits Vocal communication: language Genetic factors (development of brain) Environment (learning) Vocal communication/language Language Disorders Verbal Dyspraxia: An impaired ability to perform the coordinated movements that are required for speech In one family (KE), it appears that this disorder is caused by a mutation to the FOXP2 gene – Effects are more stronger with articulation of speech rather than comprehension Language Disorders Language development depends on experience during a sensitive period . A mutation of the FOXP2 gene delays learning to speak Figure 19.1 A Heritable Language Disorder (Part 1)
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2 Figure 19.1 A Heritable Language Disorder (Part 2) The FOXP2 Gene Transcriptional factor – Controls the expression of other genes FOXP2 gene is very different in humans than in apes, suggesting rapid evolution of this gene In several species expressed in brain areas associated with vocal learning Comparative Method Other species display vocalizations. Sounds may distinguish species, signal readiness to mate, or alert others to danger. A parallel to humans is that mice with FOXP2 mutations have impaired vocalization. Outline FOXP2 – Mutation in humans – Manipulation in mice – Expression with learning in songbirds Human language circuits Singing Mice? Mice vocalizations are ultrasonic (very high frequency) Genetically identical male mice show individual differences in vocalizations
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3 Copyright ©2005 by the National Academy of Sciences Shu, Weiguo et al. (2005) Proc. Natl. Acad. Sci. USA 102, 9643-9648 Fig. 4. Vocalization and behavior in mice with a disruption of the Foxp2 locus
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