05.12_Memory4_updated

05.12_Memory4_updated - Memory IV H.M had severe epilepsy...

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© S. J. Luck All rights reserved 1 © S. J. Luck All Rights Reserved Memory IV • H.M. had severe epilepsy and was given a bilateral medial temporal lobectomy, leading to profound anterograde amnesia with temporally graded retrograde amnesia – Anterograde amnesia: No new memories – Retrograde amnesia: No memory prior to lesion • Case history. .. • Excerpt from NPR’s Weekend Edition, 2/24/07 • Died on Dec. 2, 2008, at the age of 82 – See NY Times obituary at http://www.nytimes.com/ 2008/12/05/us/05hm.html?em H.M. Normal Lesion of medial temporal lobes, including hippocampus • Other individuals with damage to the medial temporal lobes (e.g., due to cardiac arrest or herpes encephalitis) also show anterograde amnesia • Monkeys who receive lesions of the medial temporal lobes also show anterograde amnesia – Example: Trial-unique delayed nonmatch-to-sample Wisconsin General Testing Apparatus Trial 1 Trial 2 Sample Test Delay
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© S. J. Luck All rights reserved 2 • Damage to the medial diencephalic areas (midline thalamic areas) also causes profound anterograde amnesia (Squire et al., 1989) Patient N.A. Korsakoff’s Syndrome • Damage to the medial temporal lobes or medial diencephalic areas leads to deFcits in explicit memory but not implicit memory – Normal motor learning – Normal priming (e.g., wordstem completion) – Normal “habit learning” (gradual learning on the
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05.12_Memory4_updated - Memory IV H.M had severe epilepsy...

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