Problem Set 2 Key - Problem Set 3 Page 1 of 4 Problem Set 2...

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Problem Set 2 2) Effects of the following on the p50 of Hb: a. Increase pH from 7.2 to 7.5 Increasing pH diminishes the Bohr Effect (i.e. stabilizes R state); p50 should decrease. b. Increase pCO 2 from 20 mm t 40 mm: Increasing pCO 2 will both favor carbamate formation and lower the pH, stabilizing the T state and increasing p50. c. Dissociation into monomers Dissociation will result in a molecule which behaves like myoglobin. Without intermolecular interactions to lock the protein into the T state, the molecule will be in the R state with a low p50. 3) Oxygen binding by whole human blood: a. Plot the binding curve: Estimate % saturation at: 100 mm Hg: 98% 30 mm Hg 56% b. What percent of bound O2 is delivered to the tissues? c. Assume pH = 7.4 in the lungs and 6.8 in the tissues (see Fig. 7.16) pO2 % Saturation Θ 0 0 0 10.6 10 0.1 19.5 30 0.3 27.4 50 0.5 37.5 70 0.7 50.4 85 0.85 77.3 96 0.96 92.3 98 0.98 0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1 0 20 40 60 80 100 100 30 100 98-56 % Delivered = = = 43% 98 Θ - Θ Θ Page 1 of 4 Problem Set 3 1/26/2010 http://www.michaelpready.com/mready/ProblemSet2Key.htm
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Per the figure, θ at 30 mm Hg, pH 6.8 is ~ 35% (or so – picture isn’t that good…) 7) Oxygen binding by Callianassa (ghost shrimp of Texas beaches, actually) is shown below( with the Hill Plot): a. P50 = alog(2.1) = 125 mm Hg (x-intercept is log(p50) b. nH = max slope thru the steepest part of the curve = 3.2 (by my reckoning)
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Problem Set 2 Key - Problem Set 3 Page 1 of 4 Problem Set 2...

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