Nucleotides Nucleic Acids 4511 F10

Nucleotides Nucleic Acids 4511 F10 - Nucleotides...

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ucleotides and Nucleic Acids Nucleotides and Nucleic Acids Prof. W. L. Kelly CHEM 4511/6501 Fall 2010
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Nucleotides and Nucleic Acids I. The Genomic Revolution I ucleotides and Nucleic Acids II. Nucleotides and Nucleic Acids III. DNA Stores Genetic Information IV. Nucleic Acids: Structure V. Nucleic Acids: Properties and Chemistry VI. DNA Sequencing VII. Polymerase Chain Reaction (PCR) And…if time permits… VIII. DNA Manipulation
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I. The Genomic Revolution Sample Genomes Organism Genome Size (kb) # Chromosomes 639 Escherichia coli 4,639 1 Plasmodium falciparum 30,000 14 Caenorhabditis elegans 97,000 6 Arabidopsis thaliana 117,000 5 Drosophila melanogaster137,000 4 Lehninger: Principles of Biochemistry, Nelson and Cox, 2005, W.H. Freeman and Company, New York, NY Homo sapiens 3,200,000 23
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II. Nucleotides and Nucleic Acids: The Basics
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Nucleotides are Central to Many (All?) Biological Functions Energy currency for biology Link to extracellular signals Intracellular signalling Nucleotide Vitamins (Enzyme Cofactors) DNA RNA Proteins/Enzymes/Receptors Signalling (intracellular and Amino Acids Nucleotides nd Carbohydrates, lipids, extracellular) an Nucleic Acids ps , etc.
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Lehninger: Principles of Biochemistry, Nelson and Cox, 2005, W.H. Freeman and Company, New York, NY
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Lehninger: Principles of Biochemistry, Nelson and Cox, 2005, W.H. Freeman and Company, New York, NY
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Absorption Spectra of Common Nucleotides Lehninger: Principles of Biochemistry, Nelson and Cox, 2005, W.H. Freeman and Company, New York, NY
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The Pentoses… 2’- Lehninger: Principles of Biochemistry, Nelson and Cox, 2005, W.H. Freeman and Company, New York, NY
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Nucleotides Nucleic Acids 4511 F10 - Nucleotides...

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