Nucleotides Nucleic Acids_PS9_F10

Nucleotides Nucleic Acids_PS9_F10 - CHEM 4511/6501 Problem...

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CHEM 4511/6501 Problem Set 9 1. A diploid organism with a 45,000 kb haploid genome contains 21% G residues. Calculate the number of A, C, G, and T residues in the DNA of each cell of this organism. 2. Explain why the strands of DNA molecule can be separated more easily at pH > 11. 3. Which positions in the purine ring of a purine nucleotide in DNA have the potential to form hydrogen bonds but are not involved in Watson-Crick base pairing? 4. Calculate the weight in grams of a double-helical DNA molecule stretching from the Earth to the Moon (about 320,000 km). The DNA double helix weighs about 1 x 10 -18 g per 1000 nucleotide pairs; each base pair extends 3.4 Å. For an interesting comparison, your body contains 0.5 g of DNA. 5. Amino acid residues in proteins are each specified by three contiguous bases (a codon) in DNA. What is the length of a segment of B-DNA that encodes a 50 kDa protein? Calculate the length of the same gene if it assumed an A-DNA conformation. 6. Draw the following structures and rate their relative solubilities in water (most soluble
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Nucleotides Nucleic Acids_PS9_F10 - CHEM 4511/6501 Problem...

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