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PS7 4511 F10 - P with a negative G rxn B The corresponding...

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CHEM 4511/6501 Problem Set 7 1. Voet, Voet and Pratt Chapter 11:1, 2, 4, 5, 7, 8, 9, 12, 13, 16, 18 2. RNaseA is an enzyme that catalyzes the cleavage of RNA by the following mechanism in which both histidine residues have pK a ’s near 6. (A) Using the axis above, draw what you expect the pH-rate profile to look like for this reaction: (B) Why is RNaseA unable to catalyze the hydrolysis of DNA? 3. α -Galactosidase catalyzes the reaction shown below by a reaction similar to that of lysozyme. Compound I is a potent inhibitor (but not a substrate) of α -galactosidase. Identify a structural feature of compound I that helps it to be a potent inhibitor of α - galactosidase. O O P O Base RNA-O O O O H N NH RNA N H N H O Base RNA-O OH N NH RNA N H N O P O O O H rate pH O O OH OH HO HO R O OH OH OH HO HO + HOR NH NH R NH OH HO HO I
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