CHEM 4511 PS 5 F10 Solutions

CHEM 4511 PS 5 F10 Solutions - CHEM4511PS5Fall10Solutions

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CHEM 4511 PS 5 Fall 10 Solutions 1. Because the side chain of Gly is only an H atom, it often occurs in a protein at a position where no other residue can fit. Consequently, Gly can take the place of larger residues more easily than a lager residue, such as Val, can take the place of Gly. (If sterics are the only consideration.) 2. a. Positions appearing unable to tolerate substitutions include: 6 and 9 b. Positions appearing to tolerate conservative substitution include: 2 and 10 (uncharged, bulky side chains); 1 (considered conservative in the sense that K and D are both “charged”); Positions 5 and 8 appear to tolerate some substitution, but no clear trend can be discerned for the substitutions at these two positions. c. Positions appearing to be highly variable include: 3 and 4 (and perhaps, 7 can be lumped in with this subset of “highly variable” positions) 3. Nearly 66% of the amino acid residues in collagen are Gly or Pro (and post translational products of Pro). The other amino acids are not contained in collagen at substantive levels relative to Gly and Pro, and therefore this is NOT a good source of dietary protein. Humans have three amino acids that are essential in our diet for proper nutrition: Arg, His, Ile, Leu, Thr, Lys, Met, Phe, Trp, Val. 4.
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This note was uploaded on 11/04/2010 for the course CHEM 6501 taught by Professor Wendyl.kelly during the Fall '10 term at Georgia Tech.

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CHEM 4511 PS 5 F10 Solutions - CHEM4511PS5Fall10Solutions

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