Separation and Purification of Analgesic powder

Separation and Purification of Analgesic powder - Mary...

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Mary Martinez Experimental Date: 10/13/2010 Report Date: 10/20/2010 Title of Experiment: Separation and Purification of the Components of An Analgesic Powder Partner Name: Hitasha Kalola Abstract : This experiment is a two-week process but in the first week we have separated and purified the components in an analgesic powder “Goody’s extra strength headache powder.” We first separate the acetaminophen by boiling with ethanol and then performing a suction filtration. When ethanol evaporates we are left with acetaminophen solid. We perform suction filtration once again and crystallize to attain pure acetaminophen. We then isolate and purify aspirin by first extracting the solution with ethanol and then separating with a separatory funnel. An aqueous solution is acidified and boiled to then perform yet another suction filtration to attain aspirin crystals. An organic solution is decanted and evaporated to get crude caffeine. During the second week we measured the melting points of our components and we also performed Thin Layer Chromatography, and used UV light to examine the rates and retention factors of our components. Introduction 1. Purpose: The purpose of this experiment is to separate acetaminophen, aspirin and caffeine in Goody’s extra strength headache powder. These components are also to be purified. In the second part of this lab our aim is to check how well we separated and purified the components using melting points and thin layer chromatography. 2. TLC is one of the most common experimental techniques used for estimating the purity of an organic compound. The number of components resolved, observed as spots on the TLC plate, provides an idea of the purity of the compound. Recrystallization is an extremely useful method for the purification of solid compounds. only the major component will crystallize from the solution and the minor impurities remain dissolved in the solution. The crystals are therefore formed as a pure compound. 3. Warnings: Acetaminophen: Harmful if swallowed. Causes skin irritation. Aspirin: Toxic by ingestion, Irritant, Reproductive hazard. Caffeine: Target Organ Effect, Toxic by ingestion, Irritant. May be harmful if absorbed through skin. Causes skin irritation. Causes eye irritation. CH 2 Cl 2 : May be harmful if inhaled. Causes respiratory tract irritation. May be harmful if absorbed through skin. Causes skin irritation. Causes eye irritation. Harmful if swallowed. Suspected to cause cancer. Heat sensitive. Ethanol: Highly flammable liquid and vapor. Causes skin and eye irritation. May cause respiratory irritation. Keep away from heat/sparks/open flames/hot surfaces.
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Organic Aqueous Organic Crude Caffeine 4. Flow Scheme: Showing the separation of acetaminophen, aspirin and caffeine. Treat with warm
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This note was uploaded on 11/04/2010 for the course ORGO 1 AND V.0243 taught by Professor Jones during the Spring '10 term at NYU.

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Separation and Purification of Analgesic powder - Mary...

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