vitamin b brazilian women no good

vitamin b brazilian women no good - BMC Cancer Research...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Bio Med Central Page 1 of 10 (page number not for citation purposes) BMC Cancer Open Access Research article Dietary intake of folate, vitamin B 6 , and vitamin B 12 , genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Brazilian women Enbo Ma 1 , Motoki Iwasaki* 1 , Ishihara Junko 1,2 , Gerson Shigeaki Hamada 3 , Ines Nobuko Nishimoto 4 , Solange Maria Torchia Carvalho 5 , Juvenal Motola Jr 6 , Fábio Martins Laginha 6 and Shoichiro Tsugane 1 Address: 1 Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan, 2 Department of Nutrition, Junior College of Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan, 3 Nikkei Disease Prevention Center, São Paulo, Brazil, 4 Statisitical Section/Head and Neck Surgery and Otorhinolaryngology Department, Hospital AC Camargo, São Paulo, Brazil, 5 Departamento de Mastologia, Hospital AC Camargo, São Paulo, Brazil and 6 Department of Breast Surgery, Hospital Pérola Byington, São Paulo, Brazil Email: Enbo Ma -; Motoki Iwasaki* -; Ishihara Junko -; Gerson Shigeaki Hamada -; Ines Nobuko Nishimoto -; Solange Maria Torchia Carvalho -; Juvenal Motola -; Fábio Martins Laginha -; Shoichiro Tsugane - * Corresponding author Abstract Background: Several studies have determined that dietary intake of B vitamins may be associated with breast cancer risk as a result of interactions between 5,10-methylenetetrahydrofolate reductase (MTHFR) and methionine synthase ( MTR ) in the one-carbon metabolism pathway. However, the association between B vitamin intake and breast cancer risk in Brazilian women in particular has not yet been investigated. Methods: A case-control study was conducted in São Paulo, Brazil, with 458 age-matched pairs of Brazilian women. Energy-adjusted intakes of folate, vitamin B 6 , and vitamin B 12 were derived from a validated Food Frequency Questionnaire (FFQ). Genotyping was completed for MTHFR A1298C and C677T, and MTR A2756G polymorphisms. A logistical regression model was used to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs). Results: Neither dietary intake of folate, vitamin B 6 , or vitamin B 12 nor MTHFR polymorphisms were independently associated with breast cancer risk. Analysis stratified by menopausal status showed a significant association between placement in the highest tertile of folate intake and risk of breast cancer in premenopausal women (OR = 2.17, 95% CI: 1.23–3.83; P trend = 0.010). The MTR 2756GG genotype was associated with a higher risk of breast cancer than the 2756AA genotype (OR = 1.99, 95% CI = 1.01–3.92; P trend = 0.801), and statistically significant interactions with regard to risk were observed between the MTHFR A1298C polymorphism and folate (P = 0.024) or vitamin B 6 (P = 0.043), and between the MTHFR C677T polymorphism and folate (P = 0.043) or vitamin B 12 (P = 0.022).
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 11/06/2010 for the course NS 1150 taught by Professor Levitsky during the Spring '05 term at Cornell University (Engineering School).

Page1 / 10

vitamin b brazilian women no good - BMC Cancer Research...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online