Fischer Esterification.02July2008-1

Fischer Esterification.02July2008-1 - Isobutyl Propionate...

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Isobutyl Propionate “rum” by Fischer Esterification Last update: 02 July 2008 Dr. Glenn Nomura Reference : Williamson, Macroscale and Microscale Organic Experiments , 4 th edition, Houghton Mifflin: New York, 2003, Experiment 40.2, (10 X) microscale Isobutyl Propionate by Fischer esterification, p. 560 Equation: Materials: 1. propionic acid, 1.48 g (1.50 mL, 0.01998 mol) 2. 2-methyl-1-propanol (isobutyl alcohol), 1.12 g (1.40 mL, 0.01511 mol) 3. Dowex 50X2-100 ion-exchange resin, 500 mg Procedure: Isobutyl Propionate by Fischer Esterification This reaction should be performed in the hood. *Remember to grease all joints and use Keck clips on all connections. Into a 50 mL round bottom flask fitted with a boiling chip and water cooled condenser is placed the following in any order, 1.48 g (1.50 mL, 0.01998 mol)) of propionic acid, and 1.12 g (1.40 mL, 0.01511 mol) of 2-methyl-1-propanol (isobutyl alcohol), and ca. 500 mg of Dowex 50X2-100 ion-exchange resin ( Note A ). Reflux the mixture for 1 h or more from a 50 mL heating mantle or a sand bath using heat moderate settings. LOOSELY fit a cotton plug at the top of the condenser during this time as a precaution to reduce evaporation of reactants. At the end of the reflux
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This note was uploaded on 11/06/2010 for the course CHEM 10258 taught by Professor Dr.doodoohead during the Spring '10 term at Gwinnett Technical College.

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Fischer Esterification.02July2008-1 - Isobutyl Propionate...

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