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Online Practice Passage Notes - How does CO poisoning...

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How does CO poisoning damage cells? - CO binds to cytochrome oxidase (in the ETC) and prevents the final reaction of the ETC. If the ETC is inhibited, the Krebs cycle would be backed up (and eventually inhibited), which would lead to glycolysis being inhibited. The cell would resort to anaerobic respiration. Also consider that CO is a competitive inhibitor for oxygen…and that exogenous oxygen administration is a way to alleviate CO poisoning (or putting someone in a hyperbaric chamber, or a room filled with supersaturated oxygen) - However, with very small amounts of CO, binding a CO molecule on one of the four polypeptide subunits could lead to an increase in oxygen affinity due to the cooperativity seen in Hb. If we inhibit calcium release from the SR, then there is no way for skeletal muscle to contract (because troponin would continue to cause tropomyosin to block the myosin binding site on the actin molecule, inhibiting contraction) - Remember, the troponin/tropomyosin complex is the main regulator for skeletal muscle
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This note was uploaded on 11/07/2010 for the course CBN 356 taught by Professor Merill during the Spring '08 term at Rutgers.

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