OB_Tamoxifen - Tamoxifen Routine use Reduces DNA synthesis...

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Tamoxifen Routine use: Reduces DNA synthesis and estrogen response Treatment of Breast Cancer PO (Adults): 10-20 mg twice daily; doses of 20 mg/day may be taken as a single dose. Prevention of Breast Cancer/Ductal Carcinoma in situ PO (Adults): 20 mg once daily for 5 yr. McCune-Albright Syndrome C- Therapeutic: antineoplastics Pharmacologic: antiestrogens A- Competes with estrogen for binding sites in breast and other tissues. Reduces DNA synthesis and estrogen response. Therapeutic Effects: Suppression of tumor growth. Reduced incidence of breast cancer in high-risk patients. Delayed puberty in McCune-Albright syndrome. Major side effects: CNS: confusion, depression, headache, weakness. EENT: blurred vision. CV: PULMONARY EMBOLISM , STROKE , edema. GI: nausea , vomiting. GU: UTERINE MALIGNANCIES , vaginal bleeding. F and E: hypercalcemia. Hemat: leukopenia, thrombocytopenia. Metab: hot flashes . MS:
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OB_Tamoxifen - Tamoxifen Routine use Reduces DNA synthesis...

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