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Unformatted text preview: He wrote, “With the synthetic approaches to this group we are now capable of obtaining numerous compounds that resemble, more or less, natural nucleic acids. How will they affect living organisms? Will they be rejected or metabolized or will they participate in the construction of the cell nucleus? Only the experiment will give us the answer. I am bold enough am to hope that, given the right conditions, the latter may happen and that artificial nucleic acids may be assimilated without degradation of the molecule. Such Such incorporation should lead to profound changes of the organism, resembling perhaps permanent changes or mutations as they have been observed before in nature.” Organic Chemists Degraded Nucleic Acids in Order to Determine Their Structures
At the turn of the century, nucleic At acids were isolated from wheat germ, yeast and calf thymus in order to study their structures. These studies were based on the These perspectives of organic chemists, including Walter Jones and Phoebus Levene (→), who had a...
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