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Unformatted text preview: ria during transformation. Avery et al. (1944) wrote: “Biologists have long attempted by chemical means to induce in higher organisms predictable and specific changes which…could be which… transmitted…as hereditary transmitted… characters…. the most striking characters… example of inheritable and specific alterations…that can be experimentally alterations… induced…is the transformation induced… of…Pneumatococcus.” of… Chemical Fractionation Shows that the Transforming Factor is DNA
Avery et al. (1944) fractionated the pneumatocci and meticulously isolated the various fractions and found that the transforming principle was none other than the protein-free DNA fraction. Erwin Chargaff: Prepared Mind Erwin
Hearing of Avery’s results and believing that DNA Hearing Avery’ was the genetic material, Chargaff began isolating DNA in earnest. He developed the techniques necessary to isolate gently intact macromolecules of DNA and do quantitative work. Chargaff (1950) “...started in our work from the Chargaff assumption that nucleic acids were complicated and intricate high-polymers, comparable...
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