Lect. 9 F10 - Our trusty map for our continuing road trip...

Info iconThis preview shows pages 1–5. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Our trusty map for our continuing road trip through protein transport pathways. GATED TRANSPORT VESICULAR TRANSPORT TRANSMEMBRANE TRANSPORT Mechanisms to transport proteins through membranes. following translation (post-translational): protein transport to mitochondria, peroxisome, chloroplast, ER during translation (co-translational): protein transport to endoplasmic reticulum, gateway to vesicular transport. Controlled by signal sequence interacting with translocator , a pore that threads protein through membrane. Translocator gated by signal sequence, closes after protein passes through. Diameter of translocator is small-proteins unfolded when pass through. Chaperones keep protein unfolded-assist in unidirectional protein translocation. Mechanism for inserting transmembrane proteins. Translocator opens laterally during to allow transmembrane proteins to integrate laterally into lipid bilayer. General points about transmembrane transport-our second major protein transport mechanism. Transmembrane Transport Across the Endoplasmic Reticulum ER constitutes ~50% of internal membrane space Storage site for Ca++ (keeps cytosolic Ca++ low)-sequestered by Ca++ pump. Site of synthesis and modification of lipids for membrane biosynthesis. Site of synthesis and modification for proteins-gateway to secretory pathway. Proteins destined for Golgi, lysosome or outside of cell start in the ER. Electron microscopy revealed a close association between the ER and ribosomes Two populations of ribosomes 1) Cytosolic, free ribosomes 2) Membrane-bound ribosomes...
View Full Document

This note was uploaded on 11/10/2010 for the course CBNS 101 taught by Professor - during the Spring '08 term at UC Riverside.

Page1 / 16

Lect. 9 F10 - Our trusty map for our continuing road trip...

This preview shows document pages 1 - 5. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online