Lect. 11 F10 - CellAdhesionandCellJunctions QuickTime and a...

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QuickTimeª and a Photo - JPEG decompressor are needed to see this picture. 1996 2ed place, Nikon Small World Competition, Brad Miller, Neurons in cerebral cortex of a six day old rat Cell Adhesion and Cell Junctions
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Tissues in animal cells display two architectural extremes. Epithelial tissues Connective tissues Epithelial sheets line all body cavities. The cells tightly adhere to one another via anchoring junctions. There is limited extracellular matrix (basal lamina) and cells themselves bear mechanical stress. Mechanical strength and specialized functions provided primarily by the extracellular matrix. Specialized cell types secrete the matrix and form few permanent attachments. TISSUES-The organizational basis of multi-cellular life.
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Cell Adhesion Molecules: Complex with anchoring proteins and cytoskeletal filaments to form cell-cell and cell-matrix junctions.
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Extracellular matrix CAM junctions are also important in cell-cell signaling CAM binding can activate  signaling molecules bound  to the cytoplasmic domain  of the CAM.   activate gene expression Binding of the  extracellular ligand  activates signal  transduction, resulting  in changes to gene  expression,  cytoskeleton, etc.   activate gene expression
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Four families of CAMs Cadherins Ig-superfamily Selectins Integrins
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Cadherins are the primary CAM Cadherins are the primary CAM mediating cell-cell interactions. mediating cell-cell interactions. “Classic” caherins have 5 extracellular Ca ++ binding domains Large family (> 180 mammalian cadherins!) Ca ++ binding causes extracellular portion to extend so can bind another cadherin. Velcro principal: Individual cadherin interactions are weak; multiple interactions mediate strong adhesion.
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Cadherins are also important in regulating cell motility.
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Lect. 11 F10 - CellAdhesionandCellJunctions QuickTime and a...

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