Lect. 12.F10 - C ell-Cell Signaling Pathw ays Cell...

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Cell-Cell Signaling Pathways
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A signal must be sent. - Typically, signal is a molecule secreted by cells. The signal must be received by target cell. - example: binding a specific cell surface receptor. The signal must be transduced into a biological response. - Ligand binding can induce an intracellular signaling cascade, ending with an effect on a target protein. - changes in metabolism - changes in cytoskeleton - changes in gene expression Cell signaling-the short course . .
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SI GNALS: Cell signaling molecules encompass many factors Water Soluble Dissolved gases: Nitric oxide, carbon monoxide Small molecules: Amino acids, fatty acids, nucleotides, histamine Protein growth factors: EGF, PDGF, TGFb, NGF, etc. Neurotransmitters: acetylcholine, GABA Water Insoluble Hormones: Adrenaline, Estradiol, Insulin, Testosterone Cell Surface/Matrix Bound CAMs and extracellular matrix components.
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Cell Surface Receptors: Ligands usually water soluble. Intracellular Receptors: Ligands water insoluble (hormones). Signaling molecule Receptor Signaling molecule Receptor RECEPTORS: Two broad classes depending on whether signal molecule can cross the plasma membrane Signaling molecules are often present at low concentrations. Compared to CAMs, cell signaling receptors have high affinity for their ligands.
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The molecular basis of hormonal signaling. Target cell Endocrine cell Blood Vessel Receptor A hormone is a substance secreted into the bloodstream in very small amounts from specialised endocrine cells.
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Steroid hormones bind directly to receptors on Steroid hormones bind directly to receptors on
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This note was uploaded on 11/10/2010 for the course CBNS 101 taught by Professor - during the Spring '08 term at UC Riverside.

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Lect. 12.F10 - C ell-Cell Signaling Pathw ays Cell...

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