Problem Set 1.with answers.F10

Problem Set 1.with answers.F10 - Name Fill in the blank...

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Name _________________________________ 1 Fill in the blank style questions 1. (2 pts) Two major types of microscopy covered in your discussion section are ____electron______ microscopy, which has a resolution of 0.1 nanometers, and ___fluorescence__________ microscopy, which can be used to view the distribution of specific cellular proteins (for second blank, also took immuno-electron microscopy). 2. (2 pts) Lipids that are modified by carbohydrate on the inside of the ER membrane are called ____glycolipids____________________. After transport to the plasma membrane these lipid molecules are located specifically on the ____outer/external_________________ leaflet of the membrane. 3. (2 pts) You have isolated a mutant cell line that exhibits phosphatidylserine on both the outer and inner leaflets of the plasma membrane. What sort of protein might be defective in these cells? ____flippase________________________________________. 4. (2 pts) Draw a circle around the glycerol backbone of the phospholipid shown to the right. 5. (2 pts) A transient lipid micro-domain containing sphingolipids and a sub-set of membrane proteins is called a ____lipid raft__________________. This structure is thought to represent a localized __phase transition______________ in the plane of the membrane. 6. (2 pts) At a concentration of ~10 -6 mM in the cytoplasm and 2 mM on the outside of the cell, Ca 2+ has a much steeper electrochemical gradient than Na + , which is at 12 mM in the cytoplasm and 145 mM on the outside. List two reasons why Ca 2+ has the steeper electrochemical gradient. a) _Each Ca ion has two positive charges versus one for Na, so the electrical component is steeper._ _ b) _The concentration gradient for Ca is many orders of magnitude greater than for Na. __ .
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Name _________________________________ 2 7. (3 pts) TRPA1 in the hair cells of the inner ear is an example of a _______mechanically__________ gated ion channel. The other two ways to gate a channel are ________voltage___________________ gated and ________ligand___________________ gated. 8. (2pts) List two properties that distinguish a carrier protein from a channel protein. There could be a variety of answers in addition to those listed below. a)____Carrier proteins can do active transport; channels only allow passive transport__________. b)____Transport through a channel is much more rapid than through a carrier protein.__________. 9. (3 pts) Briefly define critical concentration. Please do not use the terms k ON or k OFF . For a simple equilibrium polymer, the critical concentration is ___the concentration of free assembly subunit that is in equilibrium/steady state with polymer______. 10. (3 pts) Straight from the problem set (again). The role of _______GTP____________ hydrolysis by tubulin and ______ATP______________ hydrolysis by actin is to promote rapid __disassembly____. 11. (4 pts) The ER is stretched out to the __plus________ ends of MTs by a ___kinesin___________
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This note was uploaded on 11/10/2010 for the course CBNS 101 taught by Professor - during the Spring '08 term at UC Riverside.

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Problem Set 1.with answers.F10 - Name Fill in the blank...

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