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Lecture 5.F10 - Neuroscience 106 Lecture 5 The Action...

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Neuroscience 106: Lecture 5 – The Action Potential ASSIGNMENTS: In Bear et al study Chapter 5. TODAY'S LECTURE: The Action Potential (AP) I. The Refractory Period A. Action potentials have an absolute and relative refractory period which restricts the action potential frequency. B. The absolute refractory period ends approximately 1 ms (millisecond) after the action potential begins. Therefore the maximum AP frequency is 1000 APs/s (second). C. The relative refractory period ends approximately 3 ms after the action potential begins. Therefore it is difficult for neurons to generate APs at a rate greater than 333/s. (actually it is rare to see frequencies greater than 100 APs/s). Relative Refractory Period Absolute Refractory Period 1
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II. Mechanisms for the production of APs A. At T 1 , the AP threshold for initiation, a critical number of voltage-gated Na + channels open. B. At T 2 , the voltage-gated Na + channels inactivate. C. At T 2 , the voltage-gated K + channels are opening.
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