Practice Midterm CBNS 106 (2)

Practice Midterm CBNS 106 (2) - CBNS 106 Midterm Fall 2005...

Info iconThis preview shows pages 1–10. Sign up to view the full content.

View Full Document Right Arrow Icon
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Background image of page 2
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Background image of page 4
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Background image of page 6
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Background image of page 8
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Background image of page 10
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: CBNS 106: Midterm, Fall 2005, Version A (bubble in: name, ID# & version on your Scanton) Narne : 0 Choose the BEST answer. Unless stated otherwise, assume physiological concentrations of ions. 1. What is/are some characteristics of the metabotropic receptor pathways? 3) they have actions far away from receptors ' b) they can amplify signals c) they are usually slower than ionotrophic receptors d) all of the above e) a and b only 2. Acetylcholine applied to heart: a. acts on nicotinic receptors b; acts to increase heart rate 0. acts on a G—Protein linked receptor (1. acts to close ligand gated potassium channels e. all of the above are true 3- Which is NOT a component of the cytoskeleton a. microtubule b. nanofilament . _ c. neurofilament ,1 d. microfilament - , e. all of these are components of the cytoskeleton ' n" 4. Which, of the following are correct extracellular ion concentrations (in mM) . - a.Na= 150, Cl= 150, K= 5,Ca=.2 1). Na = 130, C1 = 130, K = 50, Ca= 0.002 c. .Na =130, C1 = 130, K = 50, Ca = 20 d. Na=15, Cl = 13, K = 100, Ca= 0.002 e. none of the above are correct ' 5. The equation used to calculate membrane potential is the: a. Nemst Equation ' ‘ b. Hearst Equation c. Golgi’s Equation d. Goldman’s Equation e. none of the above 6. Which of the following is NOT true of acetylcholine a; it binds nicotinic receptors b. it binds muscarinic receptors c. it is degraded by choline acetyltransferase (ChA'I) d. it is the main neurotransmitter of the neuromuscular junction _ e. all of the above are true 7. At a Vm of -90 mV the driving force on K would be a -80 mV A ' b. 0 mV c. -100 mV (1. -10 mV e. none of the above 8. If Cl channels suddenly Opened in a neuron held at a Vm of -60 mV a. Cl would rush out and the cell would depolerize . b. Cl would rush out and the cell would hyperpolerize 0. Cl would rush in and the cell would depoleriZe d. Cl would rush in and the cell would hyperpolerize e. none of the above 9. The rate limiting step in the synthesis of catecholamine transmitter is the conversion 01 a. tyrosine to dopa by tyrosine hydroxylase b. tyrosine to dopamine by tyrosine hydroxylase _c. tyrosine to dopa by tyrosine decarboxylase d. tryptophan to dope by tryptophane decarboxylase e. dopa to dopamine by dopa decarboxylase 10. An inhibitor of dopamine beta-hydroxylase should (extrapolate just a little) 3. reduce levels of dopamine, epinephrine and norephrine ‘ b. reduce levels of epinephrine and increase levels of norepinephrine ' c. reduce levels of dopamine only ‘ (1. increase levels of dopamine and reduce levels of noreinephrine and epinephrine e. reduce levels of norepinephrine and increase levels of epinephrine 11. Which of the following is/are true about electrical synapses? a) they couple neurons both electrically and biochemically b) there is no synaptic delay in electrical sysnapses c) the pores of their channels are formed by connexons d) they usually allow for bidirectional transmission of information e) all of the above are true 12. What is/are true about secretory granule? - a) they contain peptide neurotransmitters b) they release their neurotransmitter in response to single action potentials c) they are docked-near the voltage-gated Ca channels d) both a and c e) all of the above 13. Which of the following is/are catecholamine neurotransmitters? a) Dopamine * b) Norepinephrine ' c) Tyrosine ' , I}. d) aandb : c) all of the above w“... m... i _ M WWWW ————-——-———————————_——_———_————————_ 14. Nerve gas should 3. reduce synaptic levels of ACh and increase heart rate . b. inhibit acetylcholinesterase, increase synaptic levels of ACh and decrease heart rate c. inhibitacetlycholinesterase, increase synaptic levels of ACh and increase heart rate d. stimulate acetlycholinesterase, reduce synaptic levels of ACh and decrease heart rate > e. inhibit the synthesis of ACh 15. An overdose of morphine would best be treated by a. injection of holoperidol b. injection of atropine c. injection of 'ITX d. injection of alpha—methyl-para~tyrosine 6. injection of naloxone 16. Which is NOT a mechanism of neurotransmitter inactivation a., enzymatic degradation b. reuptake , 0‘. receptor desensitization d. uptake by astrocytes e. diffusion out of the synaptic clefi 17. Which of the following has NOT been mentioned as, a neurotransmitter candidate a. glutamate - b. GABA . c. nitric oxide d. ATP e. cGMP 18. Which of the following cell types has the greatest capacity for spatial summation? a) photoreceptor _ b) Cerebellar Purkinje‘ Neuron c) Spinal motor neuron d) Mitral cell c) astrocyte 19. Opening ligand-gated. potassium '(K+) channels on the post—synaptic resting membrane will; a) cause an EPSP and potassium influx ' b) potentially lead to the initiation of an action potential c) depolarize the post-synapticmembrane (1) cause an IPSP and potassium efflux e) a, b & c 20. The spaces between adjacent oligodendroglia are called a) gap junctions ‘ b) sarcomeres c) nodes of Ranvier d) saltatory gaps _ 1 e) nodes of Schwann 21. The action potential threshold is a. due to the inactivation of V-gated Na channels b. the voltage at which there is a net influx of cations c. the voltage at which there is a net efllux of cations .d. the voltage at which there is a net influx of anions e. the voltage at which there is a net efflux of anions 22. Suddenly increasing the intracelluar K+ concentration of a neuron at rest will? a. hyperpolarize the neuron b. depolarize the neuron V c. not change the membrane potential d. all of the above e. first hyperpolarize and then depolarize the neuron 23. Which of the following would cause a resting neuron to hyperpolan'ze a. an influx of cations b. an efflux of anions c. an decrease in the permeability of the membrane to K d. an increase in the permeability of the membrane to Na e. none of the above 24. Which of the following is NOT true of action potentials a they are always depolarizing b. they have a threshold for initiation A _ c. their conduction-Velocity is increased by decreasing membrane resistance ‘ (1. they can travel along an axon in either anterograde or retrograde directions e. all of the above are true of action potentials. ' 25. The falling phase of an action potential is produced by a. K influx and increased membrane permeability to K b. K efflux and increased permeability to K 0. Na influx and increased permeability to Na (1. Na efflux and increased permeability to Na .6. none of the above ' - 26. Voltage-gated Na channels . a. are opened almost immediately by depolarization ' b. open and close repeatedly in response to depolarization c. are rare in the nodes of Ranvier d. are responsible for the relative refractory period - e. none of the above 27- Voltage-gated K channels » A a a. are responsible for the rising phase of the action potential b. are responsible for the absolute refractory period c. are responsible _for the relative refractory period (1. are ‘most concentrated in the membrane of the somata and dendrites e. none of the above 28. Which is true of NaTIK”r pumps ' ' a. they transport Na+ out of the cell and transport K+ into the cell. b. they usually transport Na+ and K in a 2:1 ratio . c- they are stimulated by increased intracellular concentrations of K (1. their activity depends on calcium influx e. all of the above v ' 29- Myelinated axons a. produces larger action potentials b. generate action potentials at a higher frequency c. produces longer lasting action potentials d.'conducts action potentials more rapidly e. none of the above . 30. Which of these do NOT occur during an action potential a. voltage—sensitive Na+ channels open b..voltage-sensitive K+ channels inactivate - c. voltage-sensitive K+ channels open d. voltage-sensitive Na+ channels inactivate - c. all of these occur during an action potential 31. The C1' equilibrium potential of a neuron placed in a solution containing 13 mM Cl- will be: a. more negative than ~65 mV b. _—65mV c. ~29mV d. OmV e. 29inV 32. A neuron in an extracellular solution with 0.0002 mM calcium will a. generate action potentials but" not release neurotransmitter b. not generate action potentials and not release neurotransmitter b. generate action potentials and release neurotransmitter ‘ generate low amplitude action potentials that do not reach the presynaptic terminal e. none of the above. I 33. The sequence of steps that produces neurotransmitter release from the terminal is: a. vesicle firses with. membrane > depolarization > open V-gated Ca channels >' Ca influx b.. depolarization > Ca influx > open V—gated Ca channels > vesicle fuses with membrane c. Ca influx > depolarization > open V~gated Ca channels > vesicle firses with membrane d. open V—gated Ca channels > Ca influx > depolarization > vesicle fuses with membrane e. depolarization > open V-gated Ca channels > Ca influx > vesicle filses with membrane 34. Which of the following provide peripheral axons with myelin? a oligodendrocytes r b. microglia c. astrocytes d. phagocytes e. Schwann cells- 35. The myelin sheath: . ‘ a. Increases R; ' b. Decreases R; _ c. Increases Rm d. Decreases RnI e. none of the above are correct 3'6. Which of the following should have the fastest action potential conduction velocity? a. an unmyelinated, small-diameter axon b. an unmyelinated, large-diameter axon c. a myelinated, small—diameter axon d. a myelinated, large~diameter axon e. they would all have the same conduction velocity 37. Which of the following sets of equilibrium potentials is correct - ' a. BK = ~80 mV, Em: ~62 mV, Eg=-65 mV, Bea = 123 mV b. Ex = -80 mV, EN, = 62 mV, Ea = —65 mV, EC, = -123 mV c. EK= 80 mV, ENa= 62 mV, ~EC; =—65 mV, ECa= 123 mV cl. .EK = 80 mV, ENa= -62 mV, EC. = -65 mV, Bea =123 mV- 'e. None of the above 38. Which of the following Statements is FALSE? a. a neuron’s membrane at rest is more permeable to Ki than to Na+.. b. Na+/K+ pumps are activated by an increase in the intracellular concentration of Naf - c. At the peak of the actiOn potential [N a]; is higher that [Na]0 , d. none of the above are false e. all of the above are false 39. An IPSP could be produced by opening which of the following channels a ligand-gated Na)r channels b. voltage-gated Na+ channels c.1i'gand—gated K+ channels (1 ligand—gated Cl' channels e. C and D 40. Which of the following is incorrect a. neurons act to receive, integrate and transmit information b. the human brain contains ~ 100 billion neurons c. neurons receive and average of ~ 5000 synaptic inputs d. there are ~ 10 times more neurons than glia in the human brain - e. astrocytes have receptors for neurotransmitters 41.- Which of the following is NOT important in saltatory conduction a voltage—gated Ca++ channels b. the myelin sheath surrounding the axon c. the node of Ranvier ' d. passive current flow within some regions of the axon e. voltage-sensitive Na+ channels 42. The neuronal membrane is a barrier to ions because the ions ‘ ’ a. are hydrated and thus repelled by the hydrophobic lipid region - . b. are hydrated and attractedto the hydrophilic phosphate head region of the phospholipid molecules 3 5,; c. are repelled by the hydrophobic phosphate head region (1. are hydrated and thus attracted to the hydrophilic lipid tail region e. none of the above 43. The membrane potential would be depolarized by aKrushingin or Cl rushingin .’ ' _b. K rushing in or Cl rushing out c. K rushing out or Cl rushing in d. K rushing out or Cl rushing out e. none of the above 44. Which of the following would causea resting neuron to depolarize a. increasing the temperature and increasing extracellularK concentration b. increasing the temperature and decreasing extracellular K concentration ’ c. decreasing the temperature and increasing extracelluar K concentration d. decreasing the temperature and doubling boih intra and extracellular K conccntrations ' e. none of the above ' ' 45. A change in Vm from rest to —40 mV would - ' ; a. increase the driving force on K and increase the driving force on Na b. increase the driving force on K and decrease the driving force on Na ‘ c. decrease the driving force on K and decrease the driving force on Na ‘ a I _ d. decrease the driving force on K and increase the driving force on Na ; e. result in a driving force of 0 dn both K and Na ' _ 9 46. The membrane is refractory to the production of action potentials during the undershoot because a.,the V-sensitive Na channel are in the inactivated state 5 b. the V—sensitive K channels are closed 0. the ligand gated K channels are closed (1. the V—sensitive K channels are Open e. none of the above is correct ' 47. It is logical to think that GABA is inhibitory because a. most of the receptors subtypes it binds and activates are permeable to Na b. most of the receptOr subtypes it binds and activates are permeable to K or to Cl c. most of the receptors subtypes it binds and activates are permeable to both Na and K' d. most of the receptors subtypes it activates are G-Protein linked ‘ e.‘ none of the above ' .‘v 48. Newly synthesized enkephalin should be transported in the axon' _ . 1 a. in the retrograde direction by dynein along micofilaments at 1000 mm/hr * , b. in the anterograde direction by kinesin along microtubules at 10 min/day a c. in the anterograde direction by dynein along microfilaments at 1000 min/hr " - ' d. in the retrograde direction by dynein along microtubules at 1000 mm/day . _ e. in the anterograde directidn by kinesin along microtubules at lOOOmm/day ‘ . .1 49. What is a primary function of the myelin sheath? - V ' a. to supply nutrients to the axon ‘ ' ‘ ' b. to carry wastes from the axon c. to decrease the metabolic energy needed for action potential conduction d. to actively transport potassium ions e. to regulate the difiirsion of sodium ions across the synapse 50. Which of the following may lead to an aetion potential being initiated? a) cations entering the neuron ‘ - b) anions leaving the neuron . c) anions entering the neuron d) cations leaving the neuron e) both a and b 51. Which of the following is/are true about the relative refractory period? a) another action potential can be generated during this period ‘ b) the membrane is highly permeable to K during this period c) voltage gated Na channels are inactive during this period d) all of the above 6) both aand b 52. The-ENa of a neuron in which the [Na] on the inside and outside are both doubled a) 124 mV ‘ ' b) 62 mV c) 31 mV d) -31 mV e) —62mV. 53. Which of the following is/aretrue about the absolute refractory period? a) voltage-gated Na channels are inactivated b) the membrane is highly permeable to K c) another action potential can be generated but intense depolarization is required (I) both a and b e) all of the above 54. Which is true in of neuron at —65 mV if Cl‘ channels suddenly open a) the resting membrane potential does not change ' ' b) the membrane becomes more permeable to Cl 0) there is no driving force on C1 d) the membrane reaches, or is at, the equilibrium potential for C] e) all of the above ' ' 55. . If the intracellular and extracellular concentrations of sodium is matched to that of Calcium, then: a) the equilibrium potentials of the two ions would also be identical ' b) the equilibrium potential of sodium would be twice that of calcium c) the equilibrium potential of sodium would be half that ‘of calcium =d) none of the above are correct e) there isn’t enough information to answer this question 0 Prof Stanley took sadistic pleasure in deriving this question (Guilty: but you don’t have an “1” option) 56. When the membrane of a neuron at rest becomes permeable to Na _ ‘ » a) the membrane potential approaches the equilibrium potential for Na b) the membrane becomes hyperpolarized c) Na ions move out of the neuron d) both a and c e) all of the above 2 57. Presynaptic inhibition .. r _ ~ a. decreases the release of neurotranSmitter by» the recipient “bi g” terminal b. increases IPSP amplitude . c. increases the duration of the action potential in the recipient terminal d. increases the synaptic delay ' e. none of the above 58. An overdose of which of the following might producc Parkinson’s Disease like symptoms? a) atropine _ - b) naloxone ’ c) haloperidol d) cocaine e) T'I‘X 59. Which of the following is NOT true about post synaptic potentials? a) they propagate without decrement ' b)‘ they vary in amplitude and duration 0) they vary in sign d) they have no threshold 7 e) they usually originate in dendrites and somata 60. In a complex PSP: a) each of the waveforms is due to the actions of a different neurotransmitter _h b) the PSP are either IPSP or EPSP but not both ' c) each PSP waveform is produced by activation of a different receptor subtype d) each of the individual PSP begin and end at the same time e) the PSPs are each caused by an increased in the permeability to potassium. Question # (DWKIQO'IAOJNA 10 11 12 13 14 15 16 17 18 19 , 20 21 22 23 24 25 26 27 28 29 30 Suggestion: First take the test without looking ’at the ansWers. Answer WU>O>mOm>WOUUJmOITIWU>ITID>UOOD>UJOG Question # CBNS 106 F05 — Answers to Midterm Questions 31 32 33 34 35 36 37 38 39 ‘40 41 42 43 44 45 46 47 ' 4,8 49 50 5 1 52 53 54 55 56 57 -58 59 ‘60 Answer O>O>>UZHT1memOmlUJUUJOCU>>UmOmOOMW>U ...
View Full Document

{[ snackBarMessage ]}

Page1 / 10

Practice Midterm CBNS 106 (2) - CBNS 106 Midterm Fall 2005...

This preview shows document pages 1 - 10. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online