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BIPN 144 Week 4 Notes

BIPN 144 Week 4 Notes - BIPN144Week4Notes Note:..Always ,...

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BIPN 144 Week 4 Notes Note: This has not been reviewed by Dr. Bier and may have errors. Always trust the professor over these notes. Because we have only a short time before the midterm, I have decided that instead of doing a thorough write up of Tuesdays lecture and sending it out after the exam, I will do an abbreviated write up, focusing on key features and send it out now. Signaling in the vertebrate neural tube . The top image illustrates a normally forming neural tube. As in the partitioning model of the fly neuroectoderm, there are two opposing factors which are largely responsible for activating/ repressing genes. Shh (analogous to Dorsal) is active in the ventral regions and is produced originally from the notochord, and later by the floorplate. BMP’s comprise the dorsal signal. They are produced originally from the non‐neuroectoderm and later from the dorsal most portion of the neural tube. A crazy scientist did some Spemann like experiments by grafting in an additional notochord‐ this is depicted in the lower image. As you can see, it was able to alter
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the development of the neural tube and generated a second floorplate, etc. He
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  • Spring '10
  • Bier
  • Topcellsarestillintugowarstage, SonicHedgehog, Becausewehaveonlyashorttimebeforethemidterm,Ihavedecidedthatinstead ofdoingathoroughwriteupofTuesdayslectureandsendingitoutaftertheexam,I willdoanabbreviatedwriteup,focusingonkeyfeaturesandsenditoutnow

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