ta notes week 2 part 2

ta notes week 2 part 2 - BIPN144Week2Notes(part2...

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BIPN 144 Week 2 Notes (part 2) Note: This has not been reviewed by Dr. Bier and may have errors. Always trust the professor over these notes. Dr. Bier started the lecture by reviewing some key terms, and modifying the requirements for classification as a morphogen Signals ‐ act on the outside of cells (by binding to a receptor) Transcription Factors ‐ act inside the cells (by binding to DNA and either activating or repressing transcription Morphogens must: 1) Be present in a graded fashion 2) Elicit distinct responses at different concentrations [Morphogens that are signals are usually produced by one set of cells and then diffuse into a region that is not producing that signal. This (along with the sink) establishes the gradient] Dorsal, however is a weird TF morphogen. Dr. Bier then reviewed the effects of Dorsal in the developing fly embryo [figure 3‐7a] Here the top layer (yellow) is ectoderm, and will produce skin. The middle level (blue) is neural ectoderm, and will produce neurons and ventral skin. The bottom level (red) is mesoderm, and will produce fat blood and muscle. The endoderm is not shown in this image.
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Dr Bier then spent some time going over different mutant scenarios. Consider the mesoderm layer. If twist or snail were knocked out, what would happen? No Twist = no mesoderm (mesoderm genes would not be activated) No Snail = superficially the same, no mesoderm. HOWEVER, this occurs for a different reason. Mesoderm genes will be activated by twist, but nothing will
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  • Spring '10
  • Bier
  • Dr.Bierstartedthelecturebyreviewingsomekeyterms,andmodifyingthe requirementsforclassificationasamorphogen Signalsactontheoutsideofcells, )isneuralectoderm,andwillproduceneuronsandventral skin., NoSnail=superficiallythesame,nomesoderm.HOWEVER,thisoccursfora differentreason.Mesodermgeneswillbeactivatedbytwist,butnothingwill represstheexpressionofneuralgenes.Thismeansthatthecellswillbetryingto, NowconsidertheNeuroectodermlayer NoASC=Noneurons NoBrk=Crazyskinoverexpression,asDPPwillnotbeproperlyinhibitedinthe, Bepresentinagradedfashion, comparingHighaffinitybindingtoreallystrong,thick,denseVelcro. lowaffinitybindingattaches,releasesandreattachesfrequently,likeweakpoor qualityVelcro

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