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Section A06 - Week 4 Filled

Section A06 - Week 4 Filled - WEEK 4 Dan's Section BIEB 166...

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WEEK 4 Dan’s Section – BIEB 166 – Dr. Nieh Wed. 5 – 5:50 PM @ CSB 004 OH: Wed 3 – 4 PM @ York 3010 A Lecture 7: Genetics and Learning I. Knockout studies with mice A) Alpha CaMKII – A protein found in the brain, abundant in synapses of hippocampus 1. Mutants have disorganized hippocampus development and decreased spatial learning. -Morris Water Task – learning of position in reference to landmarks -other problems include trouble swimming B) Mayford developed regional and temporal control of transgenic expression by engineering a promoter sequence sensitive to levels of tetracycline . II. Learning – A Change in behavior as a result of experience A) Non-Associative Learning – Events are not associated Ex) Aplysia 1. Habituation – Decline of a stimulus when no reward/punishment in correlated a) Results in pruning of synapses in Aplysia b) Additional example – Young Turkeys 2. Dishabituation – Recovery of a response due to a strong/novel stimulus. a) Must be larger than initial response b) Can only occur after habituation 3. Sensitization – Enhancement to an unhabituated response by first presenting a strong/novel stimulus a) Increases neurotransmitter release from interneurons. 4. Short term facilitation – Increase in a response for a short duration a) Existing proteins modified 5. Long term facilitation – Increase in a response for a long duration a) New proteins synthesized from transcription and translation b) Synaptic connections branch and grow (sensitization) B) Associative Learning – Two events are associated. The first reinforces the second.
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