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Chapter 19 Notes - -Integrin mediates attachment of cells...

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Chapter 19: Cell Junctions, Cell Adhesion, & Extracellular Matrix Two building strategies: 1. Extracellular matrix 2. Cell-cell adhesions Cell Junctions 1. Anchoring junctions : includes both cell-cell adhesions and cell-matrix adhesions to transmit stresses using cytoskeletal filaments inside the cell 2. Occluding junctions : seal the gaps between cells at the upper region to make the cell sheet impermeable (tight junctions) 3. Channel forming junctions : create passageways linking the cytoplasms of adjacent cells (gap junctions) 4. Signal-relaying junctions : allow signals to be relayed at sites of cell-cell contact (chemical synapses) Adherens junctions: anchorage sites of actin filaments Desmosome junctions : anchorage sites for intermediate filaments Transmembrane Adhesion Proteins - Cadherin : mediates attachement of cell to cell (adherens junction and desmosome)
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Unformatted text preview: -Integrin : mediates attachment of cells to matrix (actin-linked cell-matrix adhesion and hemidesmosomes) Cadherins-mediate Ca 2+-dependent cell-cell adhesion-hold cells together in early embryonic tissues-cadherin adhesions become adrift/floppy if Ca 2+ is removed from extracellular medium-mediates homophilic adhesion (cadherin molecules bind to same cadherin molecules)-bind their corresponding partner at the N terminus with low affinity-Ca 2+ binds in each hinge of the cadherin molecule and prevents its flexing Cadherins link to actin filaments or intermediate filaments through their intracellular domain. The linkage depends on intracellular anchor proteins such as β-catenin and p120-catenin...
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