Unformatted text preview: -Integrin : mediates attachment of cells to matrix (actin-linked cell-matrix adhesion and hemidesmosomes) Cadherins-mediate Ca 2+-dependent cell-cell adhesion-hold cells together in early embryonic tissues-cadherin adhesions become adrift/floppy if Ca 2+ is removed from extracellular medium-mediates homophilic adhesion (cadherin molecules bind to same cadherin molecules)-bind their corresponding partner at the N terminus with low affinity-Ca 2+ binds in each hinge of the cadherin molecule and prevents its flexing Cadherins link to actin filaments or intermediate filaments through their intracellular domain. The linkage depends on intracellular anchor proteins such as β-catenin and p120-catenin...
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This note was uploaded on 11/11/2010 for the course BIO 320 taught by Professor Staff during the Fall '08 term at University of Texas.
- Fall '08
- cell biology