Chapter 20 Notes - Chapter 20: Cancer Cancer cells behave...

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Chapter 20: Cancer Cancer cells behave as undifferentiated cells . Benign tumors -tumors that grow locally without invading adjacent tissues Malignant tumors - tumors that invade nearby tissues and form secondary metastases Most cancers are derived form a single abnormal cell that experienced some heritable change. Cancer cells contain somatic mutations -heritable due to a genetic change or epigenetic change -cancer cells are usually not inherited A single genetic mutation is sufficient to cause cancer -accumulation of random mutations leads to the development of cancer -the incidence of cancer rises with age Tumor Progression -cancer arises from a population of abnormal cells or descendants of single abnormal ancestor who evolve from bad to worse to flourish and multiply Harsh environment inside a tumor -low levels of oxygen -scarce nutrients -other natural barriers to growth Cancer cells acquire mutations that inactivate checkpoint control mechanisms if DNA is damaged. Cancer cells avoid replicative cell senescence
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Chapter 20 Notes - Chapter 20: Cancer Cancer cells behave...

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