ROS case answers

ROS case answers - Bio141 another exciting case study: this...

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Bio141 another exciting case study: this one by our own Chris Jackson on antioxidants 11.02.2010 eisen: Part I, so nothing to turn in. . . Electron transport is vital to meeting the energetic needs of the body by facilitating the production of ATP via oxidative phosphorylation. At the same time though, the ETC produces reactive oxygen species that contribute to aging. Cellular aging is the progressive loss of function due to factors such as the degradation of proteins or DNA, which often results in cell death or cancer. Research has focused on genes that might be involved in accelerating or decelerating aging due to the ETC. Ishii and colleagues ( Mitochondrion Dec, 2006) explore the role of the SHDC gene, which encodes the succinate dehydrogenase cytochrome b large subunit of ETC Complex II. Complex II catalyzes electron transport from succinate to CoQ. Ishii et al studied this gene in a common model system , the worm C. elegans . Researchers find that SDHC worm mutants have significantly greater ROS production than wild-type. Also, the activity of Complex II is reduced 80% in the mutants. Part I 1. Do you expect SHDC studies in the worm to be relevant to human biology? Why or not? 2. What is oxidative phosphorylation and why does the process generate so much ATP? a. How much ATP is produced in a process that is how efficient? b. At what steps in the process are ROS (reactive O 2 - species) produced? How and why? 3. During oxidative phosphorylation, what roles do NADH, FADH 2 , Complexes I- IV, and ATP synthase play in the production of ATP? From what processes are they generated? 4. Using a labeled diagram, illustrate how electrons are transferred from Complexes I-IV, starting with the transfer of electrons from NADH in Complex I. 5. During this electron transfer to Complexes I-IV, what specifically is happening, at the chemical level, to the complexes that comprise the ETC? Consider every redox reaction. a.
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ROS case answers - Bio141 another exciting case study: this...

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