Lec 4 - 1 Fate Specification and Symmetry Breaks Outline 1....

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Unformatted text preview: 1 Fate Specification and Symmetry Breaks Outline 1. Introduction to C. elegans 2. Asymmetric cell division as a way of creating breaks parsing cytoplasmic determinants asymmetrically in early development - the P granules & PAR genes of C. elegans 3. Induction v lateral specification (generally) equivalence groups binary switch notch signaling pathways as examples of JUXTACRINE signaling C. elegans AC/VU fates C. elegans VPC fate specification 4. Maintenance of a differentiated state 4 mechanisms Transcriptional positive feedback Chromatin remodeling Autocrine reinforcement/maintenance Paracrine reinforcement/maintenance Figure 5.42 The nematode Caenorhabditis elegans 2 Figure 5.42 The nematode Caenorhabditis elegans (Part 2) Time lapse of C. elegans Development 2 Figure 5.42 The nematode Caenorhabditis elegans (Part 2) Time lapse of C. elegans Development 3 Figure 5.42 The nematode Caenorhabditis elegans (Part 2) Figure 5.44 Segregation of the P-granules into the germ line lineage of the C. elegans embryo 4 P granule movement - first division Figure 5.43 PAR proteins and the establishment of polarity...
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Lec 4 - 1 Fate Specification and Symmetry Breaks Outline 1....

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