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12 - Lecture 12 Forces that stabilize proteins Friday...

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Lecture 12: Forces that stabilize proteins Friday, August 20, 2010
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Revisiting some of the concepts we talked about earlier this semester, how do the various types of non-bonding interactions serve to stabilize the protein fold? Friday, August 20, 2010
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ELECTROSTATIC Forces: There are a number of types of electrostatic interactions that contribute to protein stability. a. Ionic interactions . Again, governed by Coulomb’s law: The energy of association of two point charges is: U = k • q 1 • q 2 / D • r On the surface of the typical protein, there are many charged residues, which often form ion-pairs or SALT BRIDGES that contribute to the net stability of the protein. However, because of the in uence of the high dielectric medium and the presence of many ions (Na+ and Cl-), their in uence on the overall stability of a typical protein in severely limited. Two exceptions: 1. Buried salt bridges. 2. Thermophilic proteins.
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