12 - Lecture 12: Forces that stabilize proteins Friday,...

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Lecture 12: Forces that stabilize proteins Friday, August 20, 2010
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Revisiting some of the concepts we talked about earlier this semester, how do the various types of non-bonding interactions serve to stabilize the protein fold? Friday, August 20, 2010
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electrostatic interactions that contribute to protein stability. a. Ionic interactions . Again, governed by Coulomb’s law: The energy of association of two point charges is: U = k • q 1 • q 2 / D • r On the surface of the typical protein, there are many charged residues, which often form ion-pairs or SALT BRIDGES that contribute to the net stability of the protein. However, because of the influence of the high dielectric medium and the presence of many ions (Na+ and Cl-), their influence on the overall stability of a typical protein in severely limited. Two exceptions: 1. Buried salt bridges. 2. Thermophilic proteins. Friday, August 20, 2010
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This note was uploaded on 11/12/2010 for the course CHEN 3320 at Colorado.

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12 - Lecture 12: Forces that stabilize proteins Friday,...

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