7 - Lecture 7: Primary structure of proteins Tuesday,...

Info iconThis preview shows pages 1–7. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Lecture 7: Primary structure of proteins Tuesday, September 7, 2010 The structure of proteins can be described on four levels Tuesday, September 7, 2010 Primary structure (1°): amino acid sequence Secondary structure (2°): local spatial arrangement of amino acids in the protein Tertiary structure (3°): three-dimensional architecture of a single polypeptide chain Quaternary structure (4°): arrangement of multiple polypeptides into a functional complex Tuesday, September 7, 2010 Primary structure of a protein describes the exact linear sequence of amino acids comprising a polypeptide chain as well as disulfides present. Tuesday, September 7, 2010 How do we determine protein sequence? Today, most protein sequence is determined by sequence its DNA gene, and using the genetic code, translating the DNA sequence into a protein sequence. However, this may not yield the final, active sequence; we often need to directly sequence the protein itself. Tuesday, September 7, 2010 Investigating aspects of a protein’s composition and sequence 1. The amino terminal sequence of a protein can be elucidated using a technique called EDMAN DEGRADATION.technique called EDMAN DEGRADATION....
View Full Document

This note was uploaded on 11/12/2010 for the course CHEN 3320 at Colorado.

Page1 / 23

7 - Lecture 7: Primary structure of proteins Tuesday,...

This preview shows document pages 1 - 7. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online