10 - Lecture 10: Chemical Evolution Friday, August 20, 2010...

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Lecture 10: Chemical Evolution Friday, August 20, 2010
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Evolution, distilled down to its essence, is any process that involves three things: 1. replication/reproduction . Obviously, the object undergoing evolution must somehow be able to make copies of itself (preferably, imperfect) 2. mutation . If an object does not mutate (change in some form), it will endless replicate without alteration 3. selection . In a population of objects, some objects must be favored, such that they are given a greater probability of replicating and carrying information, in some form, forward. Friday, August 20, 2010
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This process, is the one principle that binds biology and other felds (computational sciences--genetic algothrims!) together. To underscore that evolution is a process that can be observed, we can perForm an “in vitro” evolution experiments with a molecule called RNA, a molecular cousin oF DNA, that contains the remarkable property oF both being able to carry genetic inFormation (like DNA, and thus be replicated) and perForm Functions such as Friday, August 20, 2010
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This experiment takes the form of a process called “SELEX” (systematic evolution of ligands by exponential enrichments) Friday, August 20, 2010
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At the end of the procedure (usually 10 rounds of selection and ampliFcation), you get a few “winner” sequences, that have been shown to have the desired property All the winners have a sequence containing: The 3-dimensional structure of the RNA clearly contains a bound ATP molecule: Friday, August 20, 2010
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10 - Lecture 10: Chemical Evolution Friday, August 20, 2010...

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