Unformatted text preview: Asp residue would be more disruptive. (c) Glu. The amide-containing Asn would be a better substitute for Gln than the acidic Glu. (d) His. Pro’s constrained geometry is best approximated by Gly, which lacks a side chain rather than a residue with a bulkier side chain such as His. 3. Yes, although such irregularity, while often called “random coil” is not truly random, as the irregular structure would be fixed into a discrete native state. 4. Hydrophobic effects, van der Waals and hydrogen bonds are destroyed during denaturation. Covalent crosslinks (Voet & Voet!) are retained....
View Full Document
- Van der Waals, hydrophobic residues, positively charged Lys, coherent folding process, oppositely charged Asp