15 - Lecture 14: Hemoglobin and ligand binding Monday,...

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Lecture 14: Hemoglobin and ligand binding Monday, August 23, 2010
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As a normal part of protein and enzyme function, they often bind other proteins, small organic molecules, nucleic acids, inorganic substances, etc. This binding of these molecules, called LIGANDS, is reversible and transient , an extremely important property of biologically active proteins. The site on the protein that binds another molecule is called the BINDING SITE. This site often has several key characteristics: Monday, August 23, 2010
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1. It is complimentary to the ligand in shape, size, charge, and hydrophobic or hydrophilic character. 2. It is SPECIFIC. The protein can discriminate among thousands of di±erent molecules in the environment and selectively bind only a few. 3. The binding site is often FLEXIBLE. Binding of the ligand can induce local conformations in the binding site or global conformational changes in the entire protein. These changes are often essential to the protein’s function. 4. Interactions between proteins and ligands are often REGULATED, usually through the binding of other ligands. The binding of these regulatory ligands a±ect the binding of the ²rst ligand through a number of means. Monday, August 23, 2010
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transport them throughout the body is HEMOGLOBIN, the primary oxygen carrier in animals, and its related protein MYOGLOBINS. A single globin-fold polypeptide contains a molecule called HEME
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15 - Lecture 14: Hemoglobin and ligand binding Monday,...

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