16 - Lecture 16: Cooperativity and the mechanism of oxygen...

Info iconThis preview shows pages 1–7. Sign up to view the full content.

View Full Document Right Arrow Icon
Lecture 16: Cooperativity and the mechanism of oxygen uptake by hemoglobin Monday, August 23, 2010
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
How can we rationalize the structure of hemoglobin with its oxygen binding characteristics? The unbound and bound states of hemoglobin have slightly diFerent structures. The unbound form (referred to as the T, or tense, state): Monday, August 23, 2010
Background image of page 2
The bound form, referred to as the R (or relaxed) form The relaxed form has a signiFcantly higher affinity for oxygen than the tense form. Monday, August 23, 2010
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
But, the tense form is the more stable version of hemoglobin: it is stabilized by a series of electrostatic interactions between the subunits: Monday, August 23, 2010
Background image of page 4
Thus, when oxygen is not bound, hemoglobin adopts the more stable T state, with its own low affinity oxygen binding curve Monday, August 23, 2010
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Oxygen binding to the heme group induces a small change in the conformation of the subunit to which it is bound Monday, August 23, 2010
Background image of page 6
Image of page 7
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 11/12/2010 for the course CHEN 3320 at Colorado.

Page1 / 25

16 - Lecture 16: Cooperativity and the mechanism of oxygen...

This preview shows document pages 1 - 7. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online