Exam1_key_F2008

Exam1_key_F2008 - Name: _KEY_ Author Number: _ BioC 4332...

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Name: ______________KEY ____________ Author Number: _____ 1 |________| BioC 4332 Exam I September 30, 2008 Instructions: NO calculators, iPods, cell phones or electronic devices. Write your name and author number on every page. Read the questions carefully. The exam has 100 points.
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Name: ______________KEY ____________ Author Number: _____ 2 |________| Multiple Choice CIRCLE the letter of the choice that BEST completes the statement or answers the question. (2 pts each) 1. Which enzyme is an RNA-directed DNA polymerase? a. DNA polymerase I b. DNA polymerase III c. primase d. RNA polymerase E. TELOMERASE 2. The proofreading activity of DNA polymerase III is important in: a. repairing nicks in the sugar phosphate backbone. b. removing RNA primers. c. identifying apurinic sites. d. repairing double stranded breaks. E. NONE OF THE ABOVE. 3. What is the role of the sliding clamp in DNA replication? a. It prevents formation of internal hairpins in single stranded DNA. b. It regulates helicase activity. C. IT INCREASES THE PROCESSIVITY OF THE DNA POLYMERASE III. d. It enhances the 3' to 5' exonuclease activity. e. None of the above. 4. Which statement about DNA replication is FALSE ? a. dnaA binds oriC. b. In prokaryotes, helicase is a hexamer of the dnaB protein. c. Helicase and primase are physically associated. d. Helicase hydrolyses ATP to separate the DNA strands. E. NONE OF THE ABOVE ARE FALSE. 5. Which statement about replication of eukaryotic chromosome ends is true? A. THE LEADING STRAND COULD THEORETICALLY BE REPLICATED ALL THE WAY TO ITS END. b. The lagging strand is left with a 5’ overhang of unreplicated DNA. c. Telomerase extends the 5’ overhang by synthesizing DNA in a 3’ to 5’ direction. d. Telomerase does not need a primer. Like all DNA polymerases, telomerase does need a primer. It does not need an external template because it carries along an internal template. e. None of the above are true. 6. All are correct about DNA ligase EXCEPT: a. It joins Okazaki fragments together. B. IT IS NOT REALLY NECESSARY FOR COMPLETE DNA REPLICATION. c. It can seal nicks in DNA. d. It catalyzes the formation of a phosphodiester bond in double stranded DNA. e. It hydrolyzes ATP. 7. A mutation in the gene encoding DNA polymerase I would prevent:
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Name: ______________KEY ____________ Author Number: _____ 3 |________| a. origin licensing b. DNA unwinding c. synthesis of primers D. REMOVAL OF PRIMERS e. coordination between leading and lagging strand synthesis 8. How does the strand-directed mismatch repair system know which strand to use as a template?
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Exam1_key_F2008 - Name: _KEY_ Author Number: _ BioC 4332...

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