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Chen Wang-cw23279 Ch 339K extra credit 1. Which of the following processes in the pyruvate dehydrogenase complex will be disrupted if an individual has a deficiency in vitamin B1? A) The synthesis of acetyl-CoA from hydroxyethyl TPP B) The synthesis of hydroxyethyl TPP from thiamine pyrophosphate and pyruvate C) The reduction of lipoamide D) The oxidation of lipoamide by FAD Answer: In the pyruvate dehydrogenase complex, thiamine pyrophosphate is a molecule that links the
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Unformatted text preview: carbonyl group of pyruvate from glycolysis. Vitamin B1 is a precursor for thiamine pyrophosphate. Because the individual lacks vitamin B1, she or he will not have enough starting materials for the synthesis of thiamine pyrophosphate. Thiamine pyrophosphate combines with pyruvate to yield hydroxyethyl TPP and carbon dioxide. Therefore the synthesis of hydroxyethyl TPP will be disrupted when the individual has a deficiency in vitamin B1. Choice B is correct....
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This note was uploaded on 11/12/2010 for the course CH 310 N taught by Professor Blocknack during the Fall '08 term at University of Texas.

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