Patho exam 3 final study guide 1. Identify the complications of diabetes. Cardiovascular disease, Stroke Nerve damage (neuropathy). Kidney damage (nephropathy). Eye damage (retinopathy). Foot damage. Skin conditions. Hearing impairment. 39. Identify the endocrine conditions associated with acromegaly. When GH excess occurs in adulthood or after the epiphyses of the long bones have fused, the condition is referred to as acromegaly. Etiology and Pathogenesis Clinical manifestations of acromegaly result from the effects on body cells from excess circulating blood levels of GH and IGF-1.21 The most common cause of acromegaly is a GH-secreting somatotrope adenoma in the pituitary gland. Approximately 75% of people with acromegaly p. 1052 p. have a somatotrope macroadenoma at the time of diagnosis, and most of the remainder has microadenomas.1 The other causes of acromegaly are hypothalamic tumors that result in excess secretion of GHRH, ectopic secretion of GHRH by nonendocrine tumors (such as carcinoid tumors or small-cell lung cancers), or, more rarely, GH secretion from nonendocrine tumors. The binding of the excess circulating GH with the GH receptors in hepatic cells triggers an excess secretion of IGF-1 from hepatic cells. Then, it is the circulating IGF-1 molecules that bind with the IGF-1 receptor molecules in peripheral tissues, which directly act to stimulate the tissue growth that produces the clinical manifestations of acromegaly. The disorder usually has an insidious onset, with symptoms often present for a considerable period before a diagnosis is made. Because acromegaly is the production
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- Spring '18
- Edward Kavle
- Pituitary adenoma, Sella turcica