Lecture4 - 1 and E 3 6 PDH complex dihydrolipoyl...

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1 Pyruvate dehydrogenase complex links glycolysis to TCA cycle Pyruvate translocase transports pyr into mitochondrial matrix Mitochondria are the cell’s oxidation power house
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2 Pyruvate translocase transports pyruvate into mitochondrial matrix Pyruvate dehydrogenase is a large multienzyme complex E 1 , E 2 , E 3
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3 Pyruvate dehydrogenase core: E 2 (dihydrolipoyl transacetylase) Pyruvate dehydrogenase is a multienzyme complex that needs five co-factors ( CoA, NAD + , TPP, Lipoamide, FAD ) Pyruvate + CoA + NAD + b acetylCoA + CO 2 + NADH
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4 PDH requires coenzymes TPP and FAD and lipoamide Pyruvate dehydrogenase stage1: E 1 (PDH) decarboxylates pyruvate
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5 Pyruvate dehydrogenase stage1: E 1 (PDH) decarboxylates pyruvate PDH complex: dihydrolipoyl transacetylase stage 2: the long arm of lipoamide enables transfers between E
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Unformatted text preview: 1 and E 3 6 PDH complex: dihydrolipoyl transacetylase stage2: E 2 oxidizes hydroxyethyl- to acetyl-and transfers acetyl- to CoA PDH complex stage2: Coenzyme A (short form CoA or CoA-SH) Acyl-CoA are at a high energy (activated) form for transfer of acyl groups. Hydrolysis Δ G= -31.4 kJ/mol 7 PDH complex: dihydrolipoyl transacetylase stage2: E 2 oxidizes hydroxyethyl- to acetyl-and transfers acetyl- to CoA PDH complex: dihydrolipoyl dehydrogenase stage3: E 3 oxidizes red.dihydrolipoamide back to lipoamide and reduces NAD + to NADH 8 Summary PDH PDH is a multienzyme complex that needs five co-factors (CoA, NAD + , TPP, Lipoamide, FAD ) Summary PDH PDH needs to be converted to its reactive state...
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Lecture4 - 1 and E 3 6 PDH complex dihydrolipoyl...

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