Lecture5 - 6 TCA cycle stage 1 succinylCoA synthetase TCA...

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1 The TCA cycle gains energy (and/or carbon skeletons) 8 enzymes: stage 1 energy gain, stage 2 formation of oaa Overall net reaction: acetylCoA + 3NAD + + FAD + GDP + P i + 2 H 2 O barb2right 2 CO 2 + 3 NADH + 3H + + FADH 2 + GTP + CoA The TCA cycle gains energy (and/or carbon skeletons) 8 enzymes: stage 1 energy gain, stage 2 formation of oaa
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2 The TCA cycle gains energy (and/or carbon skeletons) Standard Δ G o ’ and physiological Δ G free energy changes TCA cycle stage 1 mechanism note: citrate synthase
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3 TCA cycle stage 1 mechanism note: citrate synthase TCA cycle stage 1: aconitase
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4 TCA cycle stage 1 mechanism note: aconitase involves a Fe 4 S 4 cluster as prosthetic group to fix citrate in the correct position TCA cycle stage 1 mechanism note: aconitase fixes citrate in a proper position
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5 TCA cycle stage 1: isocitrate dehydrogenase TCA cycle stage 1: α -Ketoglutarate dehydrogenase
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Unformatted text preview: 6 TCA cycle stage 1: succinylCoA synthetase TCA cycle stage 2: succinate dehydrogenase 7 TCA cycle stage 2: fumarase TCA cycle stage 2: malate dehydrogenase 8 Regulation of the TCA cycle The steps for energy gain are also the regulatory checkpoints green = activation red=inhibition TCA cycle control ATP & NADH: if there is enough energy, you don’t need more 9 The TCA cycle also works as central unit for anabolic reactions – can reverse directions ! The TCA cycle exit points for anabolism are α-ketoglutarate , succinylCoA and oxaloacetate 10 The glyoxylate cycle in plants and bacteria can serve as anaplerotic reaction to fill the TCA cycle with ‘carbon’ The glyoxylate cycle in plants is spatially separated from the TCA cycle. It is very active during germination ....
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