12- Muscle-1 - MuscleandMovement RoleofCalcium TTubules,...

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Muscle and Movement Structural Features of Striated Muscle Mechanism of Muscle Contraction Sliding Filament Hypothesis Regulation of Muscle Contraction Role of Calcium T-Tubules, Sarcoplasmic Reticulum
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Striated (Skeletal) Muscle
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S truc ture  o f S ke le ta l Mus c le Myofilaments: Thick filaments  are composed of  myosin, an  ATPase.  Thin filaments are  composed of  actin.
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Sliding Sliding    Filaments During contraction, both the H bands and I bands decrease in length  as the myosin thick filament  “pulls” the  actin thin filament which is anchored by  the Z-line toward the  M-line.
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Myosin-actin interactions underlying muscle fiber  contraction Figure 49.30 Thick filament Thin filaments Thin filament ATP ATP ADP ADP ADP P i P i P i Cross-bridge Myosin head (low- energy configuration) Myosin head (high- energy configuration) + Myosin head (low- energy configuration) Thin filament moves toward center of sarcomere.
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12- Muscle-1 - MuscleandMovement RoleofCalcium TTubules,...

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