Exam 1 2009 Final-3

Exam 1 2009 Final-3 - NAME _ BIOLOGICAL SCIENCES 110B-01...

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NAME _______________________________________ BIOLOGICAL SCIENCES 110B-01 Spring 2009 - FIRST EXAM DR. PAGE !!!Read This!!! !!!Follow the Instructions Carefully!!! PRINT YOUR NAME ( LAST NAME FIRST ) ON THE COMPUTER ANSWER SHEET AND BLACKEN THE CORRESPONDING BUBBLES. USE THE COMPUTER ANSWER SHEET TO ANSWER BOTH THE MULTIPLE CHOICE AND MATCHING QUESTIONS. Be sure you fill in the computer sheet carefully - responses to multiple choice questions on the printed exam will not be considered and should not be submitted as a re-grade request! I. Multiple choice (3 points each): Read each of the following questions carefully. Each question has only one best answer. 1. In response to binding of insulin, the insulin receptor A. phosphorylates a G-protein B. forms a heterotrimer C. forms a homodimer D. is activated by auto-phosphorylation E. triggers increased glucose uptake in the cell F. A and E G. C,D, and E H. A, C, and E 2. Intracellular calcium can serve as a second messenger. Which of the following molecules are parts of the G-protein coupled receptor pathway that can lead to an increase in intracellular calcium? A. Phosphatase B. Inositol triphosphate C. Adenylyl cyclase D. Protein Kinase A E. Phospholipase C F. A and B H. B & E 1
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3. The activation of hetrotrimeric G-proteins involves: A. Signal molecules bind to receptors with 7 transmembrane domains B. Exchange of GDP for GTP on the β -subunit of the protein C. Dissociation of β - subunit from the α,γ subunit complex D. Phosophorylation of the γ- subunit by PKA F. None of the above 4. The elevation of blood glucose by epinephrine involves the phosphorylation of which of the following enzymes to alter their activity: A. Adenylyl cyclase B. Protein Kinase A C. Phosphorylase Kinase D. Glycogen phosphorylase E. Glycogen synthase F. H. All of the above 5. Which of the following is true of steroid hormones? A. They bind to G-protein coupled receptors B. They bind to Receptor Tyrosine Kinases C. They typically activate the MAPK signaling pathway D. They act on cells by binding to soluble intracellular receptors E. They generally exert effects by causing changes in gene expression F. 6. Only certain cells in the body are target cells for the steroid hormone aldosterone. Which of the following is the best explanation for why these are the only cells that respond to this hormone? A. Only target cells are exposed to aldosterone B. Only target cells contain receptors for aldosterone C. Aldosterone is unable to enter nontarget cells D. Nontarget cells destroy aldosterone before it can produce its effect. E. Nontarget cells convert aldosterone to a hormone to which they do respond F. None of the above is a good explanation 7. Hormone X produces its effect in its target cells via the cAMP second messenger system. Which of the following will produce the greatest effect in the cell? A. a molecule of hormone X applied to the extracellular fluid surrounding the cell
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This note was uploaded on 11/12/2010 for the course BSCI BSCI 110B taught by Professor Johnson during the Spring '09 term at Vanderbilt.

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Exam 1 2009 Final-3 - NAME _ BIOLOGICAL SCIENCES 110B-01...

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