Lecture 22 Cell cycle

Lecture 22 Cell cycle - Lecture 22 THE CELL CYCLE (Campbell...

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Lecture 22 THE CELL CYCLE (Campbell Chapter 12 pp 228-235) Learning objectives Define the different stages of the cell cycle and what happens at each stage. Be able to describe the DNA content of a cell at each stage of the cell cycle Define a cell cycle checkpoint Describe how the cell regulates the activity of CDKs  Describe the roles of checkpoints, cyclins, and Cdks in the cell cycle control system. Describe how growth factors affect the cell cycle checkpoints. Describe how the loss of cell cycle control can result growth defects.
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Key terms that you should know G1 phase S phase G2 phase M phase G0 phase Checkpoint Cyclin Cyclin-dependent kinase (CDK) Protein kinase Protein phosphorylation MPF (M-phase promoting factor) Growth factor PDGF myostatin Chapter 12 Book problems:     Concept check 12.1, 12.2, 12.3    All of the self-quiz questions on page 234
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Regulation of progression through the  cell cycle insures that growth and DNA  replication precede cell division. The cell cycle can be divided into four phases G1   = cell growth and preparation of the chromosomes for replication  S     =  synthesis of DNA (replication) G2  =  Growth and preparation for chromosomal segregation M     =  Mitosis (nuclear division) and cytokinesis (cell division) Interphase (G1,S, G2) accounts for about 90% of the cell cycle in most cells. Note that because S occurs between G1 and G2, there is twice as much DNA per cell in G2 than in G1.
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This diploid cell is in which phase of the cell cycle? One pair of homologous chromosomes paternal set of chromosomes (n=3) maternal set of chromosomes (n=3) Diploid number of chromosomes =2n=6 1. G1 2. S 3. G2 4. M
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This diploid cell is in which phase of the cell cycle? One pair of homologous chromosomes paternal set of chromosomes (n=3) maternal set of chromosomes (n=3) Diploid number of chromosomes =2n=6 1. G1 2. S 3. G2 4. M
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This diploid cell is in which phase of the cell cycle? paternal set of chromosomes (n=3) maternal set of chromosomes (n=3) Two sister  chromatids of one  replicated  chromosome One pair of homologous chromosomes Non sister chromatids of a  homologous pair of  chromosomes Diploid number of chromosomes =2n=6 1. G1 2. S 3. G2 4. M
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This diploid cell is in which phase of the cell cycle? paternal set of chromosomes (n=3) maternal set of chromosomes (n=3) Two sister  chromatids of one  replicated  chromosome One pair of homologous chromosomes Non sister chromatids of a  homologous pair of  chromosomes Diploid number of chromosomes =2n=6 1. G1 2. S 3. G2 4. M
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FREQUENCY OF DIVISION VARIES WITH CELL TYPE. Some cells divide frequently throughout life (skin cells)
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Lecture 22 Cell cycle - Lecture 22 THE CELL CYCLE (Campbell...

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