Lecture 25 Mendelian Inheritance

Lecture 25 Mendelian Inheritance - Lecture 25 Mendelian...

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Lecture 25 Mendelian Inheritance Campbell, Chapter 14 pp 262-270 Learning Objectives   1. Define true breeding, hybridization, monohybrid cross, P1 generation, F1  generation,  and F2 generation.  2. Relate Mendel's law of segregation to events in meiosis.  3. Relate Mendel's law of independent assortment to events in meiosis. 4. Be able to to predict the phenotypic and genotypic ratios of an F2  generation from a  monohybrid or dihybrid cross.  5. Distinguish between the following pairs of terms: dominant and recessive;  heterozygous  and homozygous; genotype and phenotype. Explain  the  molecular basis for each of these descriptors. 6. Explain how a testcross can be used to determine if a dominant phenotype is  homozygous  or heterozygous.  7. Use the rules of multiplication/addition to calculate the probability that a  particular  F2 individual will be have a particular phenotype or genotype for  any number  of traits. Book assignments: Chapter 14, ALL problems by end of next lecture. Some will be on exam.
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Terms you should know Trait Hybridization P generation F1 generation F2 generation monohybrid cross dihybrid cross / trihybrid cross allele locus dominant allele recessive allele Mendel’s law of segregation Mendel’s law of independent assortment phenotype genotype homozygous heterozygous
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WHO IS GREGOR MENDEL In 1865, Gregor Mendel announced that he had worked out the rules of inheritance. Mendel is famous  today but was relatively unknown  outside Czechoslovakia in his  lifetime. He was the first scientist to  deduce clear and rational laws which  could explain the process of  inheritance.(This was before we knew  about genes and chromosomes!!) The rules which Mendel deduced from studies of peas are equally applicable  to human inheritance, so pay attention.
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The question that Mendel was trying to answer: What are the basic patterns in the transmission of traits from parent to  offspring? He wanted to test the hypotheses for inheritance that  predominated in 1865: Blending inheritance Inheritance of acquired characters  His experimental approach was to monitor and quantitate  the transmission of traits in the pea plant, Pisum sativum.
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contributed to his success in solving the problem that had confounded others before him. . Peas are a good experimental system because… -they are easy and inexpensive to cultivate. -they reproduce quickly. -they can be raised in a small space, in large numbers. -they are amenable to genetic analyses. 
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This note was uploaded on 11/14/2010 for the course CHE 131 taught by Professor Kerber during the Spring '08 term at SUNY Stony Brook.

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Lecture 25 Mendelian Inheritance - Lecture 25 Mendelian...

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