expt353_grignard - GRIG.1 ORGANIC SYNTHESIS BENZOIC ACID...

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GRIG.1 ORGANIC SYNTHESIS: BENZOIC ACID VIA A GRIGNARD REACTION TECHNIQUES REQUIRED : Reflux with addition apparatus , rotary evaporation OTHER DOCUMENTS Experimental procedure , product spectra INTRODUCTION In this experiment you will synthesise benzoic acid using bromobenzene to prepare a Grignard reagent, which is then reacted with carbon dioxide, worked-up and purified to give the acid. This sequence serves to illustrate some important concepts of practical organic chemistry : preparing and working with air and moisture sensitive reagents, the "work-up", extractions, apparatus set-up, etc . The synthesis utilises one of the most important type of reagents discussed in introductory organic chemistry, organometallic reagents. Br 1) Mg, ether 2) CO 2 3) H 3 O + OH O In this reaction the Grignard reagent (an organomagnesium reagent), phenylmagnesium bromide is prepared by reaction of bromobenzene with magnesium metal. This will then be converted to benzoic
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