GRIGNRD_ovr - Preparation of Benzoic Acid from the Grignard...

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Preparation of Benzoic Acid from the Grignard Reaction Certain compounds will react with metals to form a largely covalent bond which is highly polarized: + M R δ - δ - its reactivity is characteristic of a carbon atom with a partial negative charge on it. This reagent can then undergo two general types of reaction: 1. nucleophilic attack on a carbonyl : C O + R M δ δ δ δ C O - M + R 2. reaction as a base by abstraction of a proton from a hydroxylic solvent: R'O H + R M R H + R' O - M + δ δ Because of this reaction, it is absolutely necessary that the reaction mixture not contain any water which as is indicated above will convert the Grignard reagent to R-H. 55c14b915386bfd83641d4724d49ddcc77abc999.DOC Grig-1
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Reactions with the Grignard Reagent Reactions with aldehydes and ketones to produce a metal salt which is then converted to the alcohol by reaction with water or acid . React with carbon dioxide to give acids after
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This note was uploaded on 11/14/2010 for the course CHEM CHEM266L taught by Professor Christine during the Fall '10 term at Waterloo.

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GRIGNRD_ovr - Preparation of Benzoic Acid from the Grignard...

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