Lecture 11

Lecture 11 - C it r ic a c id c y c le Electron transport...

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Lecture 11 Citric acid cycle and electron transport chain Glycolysis in cytoplasm! Citric acid cycle in mitochondrial matrix Electron transport chain in inner mitochondrial membrane Citric acid cycle Citric Acid Cycle 2 H 2 O H 2 O No O 2 needed, but the amount of NADH generated can only be oxidized with O 2 ! Acetyl-CoA (C2) dehydrogenase dehydrogenase dehydrogenase dehydrogenase Citric acid cycle completely oxidizes the 2-C acetyl group to 2 CO 2 with dehydrogenases This results in 3 NADH, 1 FADH 2 , (reduced e - carriers) and 1 GTP = ATP
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uses NADH + H + and FADH 2 generated during sugar oxidation. • The flow of electrons in a series of redox reactions causes the active transport of protons across the inner mitochondrial membrane, creating a proton concentration gradient. • The protons then diffuse through proton channels down the concentration and electrical gradient back into the matrix of the mitochondria, creating ATP in the process. • ATP synthesis by electron transport is called oxidative phosphorylation . Electron transport chain The electron transport chain consists of three large protein complexes bound to the inner mitochondrial membrane, plus cytochrome c and ubiquinone. Cytochrome c and ubiquinone are hydrophobic carriers that shuttle hydrogen atoms or electrons from one complex to the next. A series of redox reactions is coupled to H
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Lecture 11 - C it r ic a c id c y c le Electron transport...

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