Lecture 10

Lecture 10 - R e g u l a ti o n o f m e ta b o l i c p a th...

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• Pathway and Enzyme Regulation • Redox reactions • Glycolysis Lecture 10 Enzyme Regulation and Glycolysis End-product or feedback inhibition regulates the whole pathway Regulation of metabolic pathways Principles governing metabolic pathways: ! Each reaction in the pathway is catalyzed by a specific enzyme. ! The operation of each metabolic pathway can be regulated by the activities of key enzymes. Multiple feedback control allows cells to adjust the ratio of different compounds (e.g. amino acids)
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• Enzyme activity can be inhibited by natural and artificial binders • Naturally occurring inhibitors regulate metabolism • Irreversible inhibition occurs when the inhibitor destroys the enzyme’s ability to interact with its normal substrate Enzyme Regulation DIPF, a nerve gas, irreversibly inhibits acetylcholinesterase • When an inhibitor binds reversibly to an enzyme’s active site, it competes with the substrate for the binding site and is called a competitive inhibitor • When an inhibitor binds reversibly to a site distinct from the active site, it is called a noncompetitive inhibitor or negative allosteric regulator ; they act by changing the shape of the enzyme in such a way that the active site can no longer bind the substrate • Allosteric regulators can stabilize the inactive form as described above, but they can also stabilize the active form (positive allosteric regulator)
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An allosteric regulator! (negative allosteric regulation)
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Lecture 10 - R e g u l a ti o n o f m e ta b o l i c p a th...

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