oct 21 - fungi and food aflatoxins and other mycotoxins...

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fungi and food aflatoxins and other mycotoxins food spoilage mushrooms: to eat or not to eat? corn smut: an edible plant pathogen fungi in food processing rotten world video - part 2 the mycotoxins produced by the ergot fungus cause cancer birth defects all of the above aflatoxins produced by the fungus Aspergillus flavus four different aflatoxins colorless, ordorless, and tasteless grain may not show signs of infection produced int he field or in storage effects of aflatoxins among the most potent toxins known LD_{50} values of ~.5 mg/kg for sensitive animals (ducklings, rats, and trout) carcinogens rats fed as little as 1 ppb develop liver cancer mutagens cause change in the genetic code immunosuppressants reduce the immune system's ability to fight disease some animals relatively insensitive mice LD_{50} values of ~60 mg/kg no liver cancer reported effects of aflatoxins on people disparity of results in animal tests effects on people? human data - epidemiological studies correlation between liver cancer and aflatoxins in the diet correlation does not mean casuality
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(cant do direct causation studies with humans) liver cancer most prevalent in africa and the far east diets contain high levels of aflatoxins africa and india outbreaks of illness followed periods when food supplies were limited people ate moldy cassava or rice for as little as 3 weeks effects may depend on what is consumed with the moldy grain amount of portein in the diet inclusion of certain vitamins shown to affect the results of animal tests men and children appear more susceptible 200 [mu]g/kg can be fatal to children history first discovered in the UK in 1960 turkey X disease turkeys died mysteriously other animals also affected traced to peanut meal from brazil aflatoxins found in the meal still a problem today in the midwest conditions led to infection by A. flatus in the field much of the corn grown in the midwest was suspect concentrations increased in storage contaminated grain fed to cows
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This note was uploaded on 11/15/2010 for the course PLPA 200 taught by Professor Darcy during the Spring '08 term at University of Illinois, Urbana Champaign.

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oct 21 - fungi and food aflatoxins and other mycotoxins...

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