exam 2 notes - -raise in pH-CO 2 goes down and H + ; the...

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[Physiological Buffers] -major buffer in blood (7.4) and other extracellular fluid Carbonic acid/bicarbonate pair H 2 CO 3 HCO 3 - +H 2 O CO 2 + H 2 O H + + HCO 3 - (Breathing---Kidneys) -gaseous CO 2 dissolves in blood to form carbonic acid -carbonic acid rapidly dissociates to H + and bicarbonate Concentrations of carbonic acid in blood is very LOW -CO 2 regulated by the lungs and HCO 3 - regulated by kidneys (Medical Conditions associated with blood pH) -Alkalosis –basic blood -Acidosis- acidic blood [Alkalosis]
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Unformatted text preview: -raise in pH-CO 2 goes down and H + ; the equilibrium goes to the left-hyperventilation; need more CO 2 [Acidosis]-lowering in pH-CO 2 goes up and H + ; the equilibrium goes to the right-hypoventilation; need more oxygen ventilate [Other]-phosphoric acid species H 2 PO 4-and HPO 4-2 conjugate pair (pKa=7.2) Used to mimic cellular conditions Use the H-H equation to prepare these buffers pH < pKa H + on pH > pKa H + off How to calculate pI: pI=pKa 1 + pKa 2 /2...
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This note was uploaded on 11/17/2010 for the course BIOL 333 taught by Professor Walter during the Spring '10 term at Purdue University-West Lafayette.

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exam 2 notes - -raise in pH-CO 2 goes down and H + ; the...

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