Lecture_19_DulaiS09_DNA

Lecture_19_DulaiS09_DNA - DNA Structure and Function Bio...

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Unformatted text preview: DNA Structure and Function Bio 001 AIMS for this Lecture 1. History of DNA discovery 2. Learn how you copy your cells’ DNA so that each daughter cell gets it fair share! – this happens during S phase 3. A quick look at cloning Where does the word DNA come from? Miescher Discovered DNA • 1868 – 140 years ago • Johann Miescher investigated the chemical composition of the nucleus • Isolated an organic acid that was high in phosphorus • He called it nuclein • We call it DNA ( d eoxyribo n ucleic a cid) History of Discovery • How did we know what was transmitted via sperm? – There were many candidates • Proteins • Carbohydrates • Lipids • Nucleic Acids Griffith Discovers Transformation • 1928 • Attempting to develop a vaccine • Isolated two strains of Streptococcus pneumoniae – Rough strain was harmless – Smooth strain was pathogenic Griffith Discovers Transformation 1 Mice injected with live cells of harmless strain R. 2 Mice injected with live cells of killer strain S. 3 Mice injected with heat-killed S cells. 4 Mice injected with live R cells plus heat- killed S cells. Mice die. Live S cells in their blood. Mice live. No live R cells in their blood. Mice die. Live S cells in their blood....
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This note was uploaded on 11/18/2010 for the course SS 101 taught by Professor Denver during the Spring '10 term at Alabama.

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Lecture_19_DulaiS09_DNA - DNA Structure and Function Bio...

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