5 Synaptic Transmission

5 Synaptic Transmission - SynapticTransmission

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Lecture Overview The synapse and neurotransmitter function Variety of Neurotransmitters Neurotransmitter systems and behavior
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Discovery of the 1 st   Neurotransmitter by Otto Loewi  (1921) Used 2 frog hearts.  Heart #1 was still connected to the vagus nerve and placed in  saline.  Heart #2 was in a 2nd chamber that was connected to chamber 1.  Thus, saline from chamber #1 was allowed to flow into chamber #2.  E- stim of the vagus nerve (attached to heart #1) caused it to slow  down. After a delay, heart #2 slowed down.  E- stim of the vagus nerve released a chemical into the fluid of  chamber #1 that flowed into chamber #2.  He called this chemical "Vagusstoff".  NT called acetylcholine
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Loewi’s Experiment
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Synaptic Transmission Pre synaptic Neuron Post synaptic Neuron
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Synapse Point where 1 neuron communicates w/ another Presynaptic membrane is typically an axon Synaptic Cleft: the empty space in a synapse Postsynaptic membrane can be: A dendrite (axodendritic synapse) A cell body (axosomatic synapse) Another axon (axoaxonic synapse)
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Synapse types
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Synapse: Important Microstructures Synaptic vesicles: organelle filled with  chemicals Active zones: site for chem release in the  presynaptic membrane. Postsynaptic membrane: site for receptors. Convert incoming chem signal to either  intracellular electrical or chem signals.
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VESICLES ACTIVE ZONE POST SYNAPTIC MEMBRANE
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Chemical Events at the Synapse Transmission of a message across the  synapse occurs by chemical  means. Neurotransmitters (NT): chemicals that  travel across the synapse and allow  communication between neurons.
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Sending the message AP arrives at terminal Cell makes NT Stores NT in vesicles Or enzymes make and  store NT AP causes NT to  release into synaptic  cleft 
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5 Synaptic Transmission - SynapticTransmission

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